Name: Chinese Artificial Menstrual Cycle Formula
【Functions and Indications】
Function: Tonify kidney and activate blood circulation. Indicated for polycystic ovary syndrome.
【Prescription Composition】
This is a sequential formula for one menstrual cycle, differing between Kidney Yang deficiency and Kidney Yin deficiency.
(1) Follicle-Stimulating Decoction: For Kidney Yang deficiency: Epimedium 10g, Horny Goat Weed 10g, Angelica sinensis 10g, Yam 10g, Dodder seed 10g, Morinda root 10g, Cistanche 10g, Rehmannia glutinosa (prepared) 10g; for Kidney Yin deficiency: Ligustrum lucidum 10g, Eclipta prostrata 10g, Salvia miltiorrhiza 10g, Yam 10g, Dodder seed 10g, Rehmannia glutinosa (prepared) 10g, Cistanche 10g, Prepared Polygonum multiflorum 10g; decoct and take orally.
(2) Ovulation-Stimulating Decoction: For Kidney Yang deficiency: Angelica sinensis 10g, Salvia miltiorrhiza 10g, Vaccinium planifolium seed 10g, Peach kernel 10g, Safflower 10g, Chicken Blood Vine 10g, Eucommia ulmoides 10g, Cyperus rotundus 6g, Cinnamon twig 3g; for Kidney Yin deficiency: Salvia miltiorrhiza 10g, Red Peony Root 10g, Ejiao 10g, Rehmannia glutinosa (prepared) 10g, Lycium barbarum 10g, Peach kernel 4g, Safflower 4g, Coix seed 15g, Cyperus rotundus 6g; decoct and take orally.
(3) Luteal Phase-Stimulating Decoction: For Kidney Yang deficiency: Donkey-hide gelatin 10g, Turtle shell gelatin 10g, Angelica sinensis 10g, Rehmannia glutinosa (prepared) 10g, Polygonum multiflorum 10g, Dodder seed 10g, Eucommia ulmoides 10g, Cyperus rotundus 6g, Cinnamon twig 3g; for Kidney Yin deficiency: Salvia miltiorrhiza 10g, Tortoise shell 10g, Lycium barbarum 10g, Ligustrum lucidum 10g, Eclipta prostrata 10g, Rehmannia glutinosa (prepared) 10g, Prepared Polygonum multiflorum 10g, Cistanche 10g, Dodder seed 10g; decoct and take orally.
(4) Blood-Activating and Menstrual Regulation Decoction: For Kidney Yang deficiency: Angelica sinensis 10g, Rehmannia glutinosa (prepared) 10g, Salvia miltiorrhiza 10g, Red Peony Root 10g, Ejiao 10g, Chuanxiong 4g, Cyperus rotundus 6g, Vaccinium planifolium seed 15g; for Kidney Yin deficiency: Salvia miltiorrhiza 10g, Red Peony Root 10g, Ejiao 10g, Rehmannia glutinosa (prepared) 10g, Poria 10g, Vaccinium planifolium seed 10g, Angelica sinensis 6g, Cyperus rotundus 6g; decoct and take orally.
【Differential Diagnosis and Modifications】
No modifications.
【Clinical Efficacy】
Treated 27 cases: ovulation occurred after 3 months, 24 became pregnant within 3 years (88.8%).
【Prescription Source】
Lin Zhijun, Jiangxi Second People's Hospital.
【Comment】
This treatment confirms that tonifying kidney herbs promote follicular development. The condition is classified clinically into two types: Kidney Yang deficiency with deficient Chong and Ren meridians, and Kidney Yin deficiency with stagnated heat in Chong and Ren meridians. Thickened and firm ovarian capsule acts as mechanical obstruction to ovulation, serving as evidence for blood stasis diagnosis. Thus, this formula first uses tonifying kidney herbs to stimulate follicular development; once estrogen levels rise (characteristic cervical mucus crystals appear), blood-activating and stasis-resolving therapy is applied to induce ovulation; followed by continued tonification of kidney to support luteal development, forming the "tonify kidney → activate blood and resolve stasis → tonify kidney → regulate menstruation" artificial menstrual cycle using Chinese herbs.
Professor Fu Shigui and colleagues from the Affiliated Hospital of Jiangxi Medical College have confirmed that tonifying kidney and activating blood herbs can induce follicular development and ovulation in rabbits, and found that kidney-tonifying herbs like Epimedium and Psoralea corylifolia also increase progesterone secretion in pseudopregnant rats, providing laboratory evidence for the efficacy of tonifying kidney and activating blood herbs.
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